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KMID : 0377619670130020215
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Korean Jungang Medical Journal
1967 Volume.13 No. 2 p.215 ~ p.229
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Effect of Alloxan Diabetes and Pancreattic Duct Ligation on Cholesterol Induced Atherosclerosis in Rabbits
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Abstract
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Dragstedt (1945) and Best (1948) drew attention on the significant role of the pancreas in atherogenesis through its endocrine and exocrine secretion.
Clawson and Bell (1949), Dolger (1950) and Bell (1952) found higher incidence of arteriosclerosis, peripheral gangrene, coronary diseases, and vascular diseases of the kidney among diabetics than non-diabetics based on the study of autopsy materials. Bevans (1955) stated that arteriosclerosis in diabetics involves principally the arteries of medium and small size, and LeCompte (1955) stated that sclerotic process involves also capillaries and venules characterized by deposition of hyaline substance rich in polysaccharides in the wall. In 1958 Goldenberg et al. found high incidence of non-atheromatous sclerosis of small branches of the coronary arteries in diabetic patients, and they interpreted the changes as the result of hypertension which is frequently associated with diabetes. Goldenberg et al. (1959) and Alex et al. (1959) reported that the non-atheromatous sclerosis started with swelling of endothelial cells followed by proliferation of endothelial cells and deposition of colloidal-iron negative and PAS positive 2substance in the wall.
Rabinowitch (1935) speculated that increased serum cholesterol and triglycerides in diabetics enhance arteriosclerosis. However, reports on blood lipids in diabetics and particularly its relationship to the severity of atherosclerosis are still controversial. Man and Peters (1935) reported that they found hyperlipemia in 19 out of 79 diabetics, but there was also 9 cases of hypolipemia. Pomeranze and Kunkle (1950) observed increased serum total lipids in over 50% of 273 diabetic patients, and stated that increased serum total lipids and choleterol with decreased phospholipid: cholesterol ratio cause arteriosclerosis in diabetics. However, Dewind et al. (1952) found that average serum cholesterol level is higher in diabetics than non-diabetics but its range was very wide and no definite correlation was noted between the level of serum cholesterol and severity of atherosclerosis.
Not only the disturbance of internal secretion of the pancreas but also the disturbance of external secretion seems to influence on the atherogenesis through its role on lipids absorption (Chaikoff et al. 1952).
The present investigation is aimed to investigate the role of diabetes and ligation of pancreatic duct on experimental cholesterol -induced atherosclerosis and to compare these with clinical observations.
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